Plurimen 5mg x 50 tabs
Deprenyl / Selegiline
Shipped from the UK.
Description
What is Plurimen / Selegiline (E-250 - Deprenyl) ?
The molecule Selegiline / E-250 (deprenyl) was chosen by Joseph Knoll chair of pharmacology at the Semmelweis University in Budapest as the cornersotone of his research behind the physiology of the drive to succeed. This research was later published in David Healy's 2000 article for the British journal of Psychiatry. For the further pharmaceutical development Knoll chose the l-deprenyl, R-deprenyl that has become more commonly known as Selegiline.
FREE and fast trackable shipping as standard on all orders over $149. USA ONLY.
We are now able to offer a Deprenyl / Selegiline tablet developed in the European Union. Plurimen is one of the most popular Deprenyl brands in Europe.
What is the listed use for Deprenyl (Plurimen / Selegiline)?
Deprenyl (Plurimen / Selegiline) is for the treatment of Parkinson's disease or the symptoms of Parkinsonism. Selegiline is the active ingredient in Deprenyl products. Deprenyl (Selegiline) is commonly branded as l-deprenyl, Eldepryl, Cyprenil, Selepryl or Jumex. It is a drug used for the effective symptomatic treatment of early-stage Parkinson's Disease, depression and senile dementia and is a irreversible and selective MAO-B inhibitor. In normal doses it is a selective irreversible MAO-B inhibitor, however in larger doses it loses its specificity and also inhibits MAO-A.
The enzyme monoamine oxidase MAO - has two main forms, A and B. MAO may be inhibited with agents that act reversibly or irreversibly; and selectively or unselectively. MAO-A removes the amino radical from an amino compound like serotonin, noradrenaline and also non-selectively, dopamine. MAO-B metabolises dopamine, phenylethylamine and various amines. (Amines are produced by the decay of organic matter).
Deprenyl was originally developed to "energise" the brain with anti-depressant effects. It has since been shown to protect nerve cells against a wide, and growing, number of neurotoxins, and has been shown to be a neuro-protective / neuro-rescue agent when nerve cells are exposed to damaging or stressful conditions.
As a nootropic Deprenyl (Plurimen / Selegiline) is sometimes used to treat narcolepsy and is popular with life-extensionists as there are many published life-extending effects among several species of mammals. In older males there have been positive reports on its effect on libido. Selegiline / Deprenyl's effectiveness in helping people to stop smoking tobacco or marijuana is currently being analyzed. As of February 28, 2006, selegiline has also been approved by the FDA to treat major depression using a trans-dermal patch.
Decades have passed since Professor Joseph Knoll proved that Selegiline / Deprenyl improves the availability of dopamine. In the brain, Dopamine is one of the most important substances - an essential neurotransmitter that regulates critical functions such as libido, movement, and dexterity. A reduction in dopamine levels frequently causes Depression and ultimately Parkinson's Disease.
Through frequent use of Deprenyl (Plurimen / Selegiline) this harmful dopamine decline can be decelerated, the loss of dopamine intensifies form the age of around 45 onwards, resulting in the loss of 13% of all dopamine neurons every 10 years. Once the level of dopamine loss reaches 70-80% this typically leads to Parkinson's Disease.
It was surmised by Professor Knoll that the use of Selegiline / Deprenyl from the age of 40 onwards would increase the average human lifespan by 15 cognitively healthy years.
Selegiline Tablets 5mg in detail
Each tablet contains: Active ingredient: Selegiline Hydrochloride 5mg.
Also contains Lactose Monohydrate Ph. Eur,, Microcrystalline Cellulose Ph. Eur.
Dosage: Tablets for oral use, to be taken as directed by your doctor. tablets to be swallowed whole.
Caution store below 25 degrees Celsius (77 degrees Fahrenheit). Keep out of reach of children.
What you should know about Selegiline Tablets
Please read this carefully before you start to take your medicine. This leaflet provides a summary of the information available on your medicine. If you have any questions or are not sure about anything, ask your doctor.
What is in your Selegiline Tablet?
Its active ingredient is selegiline hydrochloride Ph. Eur.
Each tablet also contain the following inactive ingredients:lactose monohydrate, microcrystalline cellulose, maize starch, citric acid monohydrate, magnesium stearate.
Selegiline is a selective monoamine oxidase inhibitor. Selegiline acts by enhancing the effects of dopamine in the brain. Dopamine is a naturally occurring substance in the brain that aids the transmission of nerve impulses. In Parkinson's disease, there is a deficiency of dopamine in the brain.
What is Selegiline for?
Selegiline is for the treatment of Parkinson's disease or the symptoms of Parkinsonism.
Before taking Selegiline
You should not take Selegiline Tablets if you:
- Are pregnant or breast-feeding.
- Are allergic to selegiline hydrochloride or to any other ingredient.
- Have liver or kidney disease
- Have duodenal or stomach ulcers
- Are already taking antidepressant drugs.
You should tell your doctor if you suffer from any one of the following, especially if they are prescribing you levodopa with Selegiline Tablets:
- Severe psychotic states (mind disorders).
- Fast or irregular heart beat
- Chest pains
- High blood pressure
- Thyrotoxicosis (Graves disease)
- Phaeochromocytoma (resulting in high blood pressure, raised heart rate, headache)
- Narrow angle glaucoma (an eye disease)
- Prostate gland disorders
You should also tell your doctor if you are taking:
- Reserpine, or related products of monoamine oxidase inhibitors (used to treat depression)
- Neuroleptics (for example, chlorpromazine)
- Medicines known as non-specific monoamine oxidase inhibitors (MAOI's). MAOI's include phenelzine or tranylcypromine, isocarboxazid or tramadol.
- Any antidepressant: for example, tricyclic antidepressants such as amytriptyline, serotonin-selective re-uptake inhibitors such as fluoxetine, or monoamine oxidase inhibitors such as phenelzine. If you are in any doubt, please ask your doctor.
- Oral contraceptives (the pill)
- Levodopa (used to treat Parkinson's disease).
Selegiline 5mg Tablets contain 48.75mg lactose per 5mg tablet. This should be taken into account in patients with diabetes.
Taking Selegiline
Follow your doctor's instructions. Always check the label for directions on how to take your medicine. You pharmacist will help if you are not sure.
The usual dose of selegiline is 10mg a day. This maybe taken as either a single 10mg dose in the morning, or as a divided dose, 5mg at breakfast and 5mg at lunch.
The tablets should be swallowed whole with some water.
If you forget to take a dose, do so as soon as you remember. It is important that the missed dose is not taken with the next dose.
If you accidentally take more than the prescribed dose, contact your nearest hospital casualty / emergency room or tell your doctor immediately.
Keep using your medicine until your doctor tells you to stop.
After using Selegiline
Selegiline may occasionally cause side effects. These include: slowness of heart rate, other effects on the heart, dry mouth, dizziness and sleeplessness.
If you are also taking levodopa with Selegiline Tablets, you may experience the following: Tiredness, cloudiness of the mind, vertigo, headache, fear, restlessness, excitation, anxious agitation, sleeplessness, anorexia, nausea, vomiting, constipation, dry mouth, muscular disorders, fluid retention, and reduction in blood pressure on suddenly standing up.
Very rarely, you may experience disorders of the mind (with confusion/hallucination), difficulty in passing water, skin reactions, breathing difficulties, irregular heart beat, spasticity and abnormal movements.
IF you experience these of any other ill effects, tell your doctor or pharmacist immediately and ask if you should continue with your medication.
WARNING: Selegiline Tablets may influence reaction time. Therefore, your ability to drive and/or use machinery may be affected. This is particularly true if you have also taken alcohol.
Keeping your medicine safe.
Do not use any medicine after the expiry date stated ont he packaging. Do not store above 25 Degrees Celsius. Keep out of the reach and sight of children; your medicine could harm them.
REMEMBER this medicine is for you. Never give it to others it may harm them, even if their symptoms are the same as yours.
Further reading about Selegiline / Deprenyl.
This product can be shipped to USA only.
Further product details coming soon.
