Centrophenoxine * Lucidril * Buy 4, Save 20%

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Centrophenoxine is one of the oldest and most well-researched nootropic on the market today.  It's used around the world for its ability to treat degenerative brain conditions, although it's recently gained popularity for its ability to enhance cognition and improve overall brain health.

√ Helps with Mood & ADHD

√ Excellent Antioxidant

√ Source of Choline to Optimize Memory

Centrophenoxine has been marketed under the trade name "Lucidril".  In medical science, Centrophenoxine has been shown to help with Alzheimer's, Dementia and general cognition.

References, Research & Articles:

Centrophenoxine: Effects on Aging

Suggested Use: As a dietary supplement take 1 or 2 capsules daily or as directed by your health care professional. 

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What is Centrophenoxine?

Centrophenoxine is made of two biochemicals, parachlorophenoxyacetate (pCPA), which is a plant-hormone resembling compound called an auxin and dimethylaminoethanol (DMAE) a natural substance found in the brain. For over 40 years Centrophenoxine has been used and studied for the treatment of Alzheimer's and Senile Dementia's and is also one of the most popular brain-energizing, anti-aging products. Do not consider this product until you have consulted with a medical professional. 

How Centrophenoxine Works?

In the Central Nervous System, Centrophenoxine increases levels of the neurotransmitter acetylcholine and enhances neuronal glucose (the main fuel for the brain) and oxygen uptake which indicate increased brain energy production. Centrophenoxine also increases neuronal RNA (derived from DNA) which tell neurons to repair cell damage and create proteins to encode memory. Lipofuscin is accumulated during our lifetime due to poor cell health and is basically biochemical garbage. When large deposits form around cells, the function becomes impaired thus causing a drop of RNA and protein production as we age. Centrophenoxine is excellent at reducing and even removing lipofuscin. Low lipofuscin levels usually mean healthy cellular function and high levels poor.

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During a study of elderly but healthy individuals, who were suffering with intellectual deterioration it was found that after only a few weeks taking Centrophenoxine they increased the storage of new information and their ability to access long term memories combined with increased vigilance and alertness.

Centrophenoxine also called Meclofenoxate but most commonly recognized under its brand name Lucidril, is one of the original anti-aging, neuro-energizing products having been used for over 40 years and studied for approximately 50. It is made from two biochemicals: DMAE and pCPA as mentioned above.

An early discovery found that Centrophenoxine effectively reduces lipofuscin levels. Lipofuscin is a fine granular yellow brown pigment, the remains or garbage accumulated over a lifetime. Considered one of the aging pigments, lipofuscin is found in most of our organs cells. The more lipofuscin in the cells, the less functional they become to a point where the cells may die. Animal and human studies have concluded that low lipofuscin levels correlates with healthy cellular function and high the opposite. Centrophenoxine has shown to be very efficient in removing this garbage.

In aged animals with high lipofuscin levels experiments showed that centrophenoxine considerable improved their memory and learning abilities.

DMAE is the major component in Centrophenoxine and DMAE, when added to the correct methyl group, creates choline which in turn helps to make valuable biochemicals like acetylcholine. When oxidized choline can make betaine which is important in ridding homocysteine - a toxic risk factor in heart disease. Choline levels are also considered to be a contributing factor in Alzheimer's Disease. Choline is found naturally in certain foods such as liver, meat and eggs.

Those lacking in these natural sources of choline could chose a choline supplement but most of these are broken down by the gut. This is not the case with the DMAE in Centrophenoxine, leaving the liver to convert it to as much choline as needed. Also, DMAE prevents choline from being irreversibly oxidized to betaine and it passes through the blood brain barrier far more easily. With the help of an enzyme called "CAT", choline is converted into acetylcholine a neurotransmitter with a responsibility for learning and memory. In Alzheimer's Disease and aging itself, cholinergic neurons tend to under produce acetylcholine.

Not to be confused with Acetylcholine itself, the popular brain nutrient ALC or Acetyl-L-Carnitine increases CAT activity, thus increasing the production of acetylcholine. It has been found that for optimizing the effect on cognitive enhancement, learning and memory, some use a combination of ALC, Centrophenoxine and Piracetam.

In a study of healthy elderly individuals who were suffering from significant intellectual deterioration, after just a few weeks, Centrophenoxine increased storage of new information into long term memory and increased vigilance and alertness. Centrophenoxine increases brain energy (ATP) production by enhancing neuronal glucose and oxygen uptake. It also increases neuronal RNA and protein production which repair damaged cells and encode memory. This function decreases with age especially when the nucleus around the cells are covered with lipofuscin and as mentioned above, Centrophenoxine reduces the levels of lipofuscin. The other component in Centrophenoxine, pCPA, is similar to plant auxins (hormones) which increase the RNA and protein production in growing plants.

Aging synapses deteriorate in their function but Centrophenoxine has been shown to increase the repair of the synapses that connect nerve cells to each other. So to conclude, due to the combination of the plant hormone like compound pCPA along with DMAE, Centrophenoxine could be best described as "the ultimate DMAE".

Centrophenoxine - the dosages

As with all products, always seek professional medical guidance before using. Caution is necessary and Centrophenoxine is a powerful enhancer of brain and peripheral nervous system acetylcholine levels. Excessive levels of acetylcholine can cause problems such as headaches, neck, jaw and shoulder muscle tension, insomnia, irritability, agitation and restlessness.

If any of these occur, simply discontinue Centrophenoxine for a few days and then try a reduced dosage. Discuss with your medical practitioner. Also, those with major depression, mania, seizure disorders or Parkinson's Disease should avoid Centrophenoxine, as too much acetylcholine may worsen these conditions. Pregnant women should avoid Centrophenoxine.

Elderly people with significant intellectual decline may chose 3 to 6 Centrophenoxine tablets (250mg) per day taken preferably with breakfast and lunch, in order to avoid insomnia. For the non-elderly wishing to utilize the brain boosting benefits of Centrophenoxine, perhaps only 1 or 2 Centrophenoxine tablets (250mg each) daily with breakfast or lunch. Excessive acetylcholine levels can accumulate virtually un-noticed so it is advisable to miss a couple of days each week. Check with your medical professional.

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References:

  1. A simple and sensitive HPLC method for quantification of the metabolin of meclofenoxate in human plasma. - Read Full Article
  2. Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson’s disease. - Read Full Article
  3. Effects of centrophenoxine on cholinephosphotransferase activity in maternal and fetal guinea pig lung.- Read Full Article
  4. Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice. - Read Full Article
  5. Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain.- Read Full Article
  6. Participation of adrenergic mechanisms in brain acetylcholine release produced by centrophenoxine. - Read  Full Article
  7. Behavioral alterations in rotenone model of Parkinson’s disease: attenuation by co-treatment of centrophenoxine. - Read Full Article

Additional Information

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Centrophenoxine (250mg x 60 capsules)

SKU Centrophenoxine-004

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